Teponi (Tepotinib) 

What Teponi is used for

Teponi contains the active substance Tepotinib.

Teponi is indicated for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) harboring mesenchymal-epithelialtransition (MET)exon 14 skipping alterations

Teponi is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that:

·has spread to other parts of the body (metastatic), and

. whose tumors have an abnormal mesenchymal epithelial transition (MET)gene. Your healthcare provider will perform a test to make sure thatTeponi is right for you.

How Teponi works

Teponi is a kinase inhibitor that targets MET, including valiants with exon 14 skipping alterations. Teponi inhibits hepatocyte growth factor(HGF)-dependent and -independent MET phospho¹ylation and MET-dependent downstream signaling pathways. Teponi also inhibited melatonin2 and imidazoline 1 receptors at clinically achievable concentrations.

If you have any questions on how Teponi works or why it has been prescribed for you, ask your doctor, pharmacist or nurse.