lvonib is an isocitrate dehydrogenase-1 inhibitor that works by decreasing abnormal production of the oncometabolite2-hydroxyglutarate (2-HG), leading to differentiation of malignant cells.

1.What  lvonib is and what it is used for

What lvonib is

lvonib is an isocitrate dehydrogenase-1 inhibitor that works by decreasing abnormal production of the oncometabolite2-hydroxyglutarate (2-HG), leading to differentiation of malignant cells.

How lvonib works

In AML, patients develop large numbers of abnormal white blood cells. ivosidenib blocks the action of certain enzymes (kinases)needed for the abnormal cells to multiply and grow, thus preventing the growth of the cancer.

2.How to take lvonib

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not

sure.

*Administer lvonib with or without food.

*Do not administer lvonib with a high-fat meal.

*Do not split, crush, or chew lvonib tablets.

*Administer lvonib tablets orally about the same time each day.

*lf a dose of lvonib is vomited, do not administer a replacement dose, wait until the next scheduled dose is due.

*lf a dose of lvonib is missed or not taken at the usual time, administer the dose as soon as possible and at least 12 hours prior to the next scheduled dose. Return to the normal schedule the following day. Do not administer 2 doses within 12 hours.

3.Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

*Common side effects of lvonib include fatigue, increase in white blood cells, joint pain, diarrhea, shortness of breath, swelling the arms or legs, nausea, pain or sores in the mouth or throat, irregular heartbeat (QT prolongation), Guillain-Barre Syndrome rash, fever, cough and constipation, Women who are breastfeeding should not take ivonib because it may cause harm to a newborn baby.