1. What Ensidnib and what it is used for 

2.How to take Ensidnib 

3.Possible side effects  

1.What Ensidnib and what it is used for  

Ensidnib was developed as a cancer medicine for the treatment of AML in adult patients whose cancer cells have a mutation  (change) in the gene for a protein called IDH2 and who cannot receive intensive cancer treatment. Ensidnib was to be used  in patients whose disease did not respond to treatment (refractory) or had come back (relapsed) after previous treatments  including a haematopoietic stem cell transplant (a transplant of cells that can develop into different types of blood cells)

How Ensidnib works  

The active substance in Ensidnib, enasidenib, works by blocking the action of mutated forms of IDH2, a protein that plays  an important role in generating energy for cells. Mutated IDH2 produces high levels of a substance called D-2-HG, which  contributes to the growth of cancer cells. By blocking the action of mutated IDH2, enasidenib is expected to reduce production of  D-2-HG and so slow down the  progression of the disease

2.How to take Ensidnib

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Your doctor will tell you what dose of Ensidnibto take.Your doctor may decide to increase or lower your dose or temporarily interrupt treatment. Continue treatment at the dose prescribed by your doctor.

•Take Ensidnib exactly as your healthcare provider tells you to

•Take Ensidnib 1 time a day at the same time each day. Ensidnib can be taken with or without food

•Swallow Ensidnib tablets whole with 8 ounces (one cup) of water. Do not chew or split the tablet

•If you miss a dose of Ensidnib or vomit after taking a dose of Ensidnib, take the dose of Ensidnib as soon as possible on the  same day. Then take your next dose the next day at your regularly scheduled time. Do not take 2 doses at the same time to  make up for the missed dose

•Your healthcare provider should do blood tests to check your blood counts before you start Ensidnib treatment and at a  minimum of every 2 weeks for at least the first 3 months during treatment to check for side effects

3.Possible side effects

The most common side effects of Ensidnib include:

•nausea

•vomiting

•diarrhea

•jaundice

•decreased appetite

Tell your healthcare provider if you have any changes to the color of your skin or the whites of your eyes.