25mg/100mg film-coated tablets

1.What Lorlatini is

Lorlatini contains the active substance lorlatinib, a medicine that is used for treatment of adults with advanced stages of a form of lung cancer called non-small cell lung cancer (NSCLC). Lorlatini belongs to the group of medicines that inhibit an enzyme called anaplastic lymphoma kinase(ALK). Lorlatini is only given to patients who have an alteration in the ALK gene, see How Lorlatini works below.

What Lorlatini is used for

Lorlatini can be prescribed to you if

*you have been previously treated with a medicine called alectinib or ceritinib, which are ALK inhibitors; or

*you have been previously treated with crizotinib followed by another ALK inhibitor.

How Lorlatini works

Loratini inhibits a type of enzyme called tyrosine kinase and triggers the death of cancer cells in patients with alterations in genes for AlK.Lorlatini is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase

If you have any questions about how Lorlatini works or why this medicine has been prescribed for you, ask your doctor.

2. How to take Lorlatini

Always take this medicine exactly as your doctor pharmacist or nurse has told you.(heck with your doctor pharmacist or nurse if you are not sure.The recommended dose is one tablet of 100 mg taken by mouth once daily.

Take the dose at about the same time each day

You can take the tablets with food or between meals always avoiding grapefruit and grapefruit juice.

Swallow the tablets whole and do not crush, chew or dissolve the tablets.

Sometimes your doctor may lower your dose, stop your treatment for a short time or stop your treatment completely if you feel unwell.

3. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Some side effects could be serious.Tell your doctor straight away if you notice any of the following side effects, Your doctor may lower your dose, stop your treatment for a short time or stop your treatment completely:

*cough, shortness of breath, chest pain, or worsening breathing problems

*slow pulse, (50 beats per minute or less), feeling tired, dizzy or faint, or losing consciousness

*abdominal (belly) pain, back pain, nausea, vomiting, itching, yellowing of the skin and eyes

*mental status changes; changes in cognition including confusion, memory loss, and reduced abilty to concentrate; changes in mood including irritability and mood swings; and changes in speech including difficulty speaking, such as slurred or slow speech