Molotinib100mg 150 mg 、200mg film-coated tablets

1.What Molotinibis and what it is used for

What Molotinib is

Momelotinib is an inhibitor of wild type Janus Kinase 1 and 2 (JAK1/JAK2) and mutant JAK2V617F, which contribute to signaling

of a number of cytokines and growth factors that are important for hematopoiesis and immune function.Molotinib is a prescription medicine used to treat adults with certain types of myelofibrosis (MF) who have anemia. It is not known if Molotinib is safe and effective in children.

What Molotinib is used for

Molotinib is indicated for the treatment of intermediate or high-risk myelofibrosis (MF), including primary MF or secondary MF [post-polycythemia vera (PV) and post-essential thrombocythemia (ET)], in adults with anemia.

How Molotinib works

This medicine is thought to work by blocking some enzymes known as Janus kinases (JAKs). These enzymes can be found in some receptors on the surface of cells and are involved in the reproduction and growth of blood cells. In myelofibrosis, JAKs are more active than normal. By blocking these enzymes, this medicine is expected to slow down the abnormal growth of blood cells, reducing the symptoms of the disease.

2.How to take Molotinib

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not

sure.

Your doctor will tell you what dose of Molotinibto take.Your doctor may decide to increase or lower your dose or temporarily

interrupt treatment. Continue treatment at the dose prescribed by your doctor.

Take Molotinib exactly as your healthcare provider tells you to take it.

• Take Molotinib by mouth 1 time each day.

• Take Molotinib with or without food.

• Swallow tablets whole. Do not cut, crush or chew tablets.

• If you miss a dose of Molotinib, skip the missed dose and take your next dose the following day at your

regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose.

• Your healthcare provider will do blood tests before you start taking Molotinib and during treatment.

• Do not change your dose or stop taking Molotinib without first talking to your healthcare provider.

• Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with

Molotinib if you have certain side effects.

• If you take too much Molotinib, call your healthcare provider or go to the nearest emergency room right away and take your

bottle of Molotinib with you.

3.Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Molotinib may cause serious side effects, including:

• Risk of Infections. People who take Molotinib may develop serious infections that can lead to death, such as bacterial and

viral infections, including COVID-19. If you have an active infection, your healthcare provider should not start treatment with

Molotinib until your infection is gone. If you have had hepatitis B for a long time (chronic), Molotinib may cause your hepatitis B

to become active again, and your healthcare provider will check your blood for active hepatitis B before starting treatment.

Your healthcare provider will monitor you and treat you for any infections that you get during treatment with

Molotinib.

Tell your healthcare provider right away if you develop any of the following symptoms of infection:

o fever

o diarrhea

o chills

o vomiting

o cough

o pain or burning feeling when passing urine

o breathing problems