1.What Pitobrunibis and what it is used for  What Pitobrunib is 

 Pitobrunib is a kinase inhibitor indicated for the treatment of 

•Adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a  BTK inhibitor. 

•Adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who have received at least two  prior lines of therapy, including a BTK inhibitor and a BCL-2 inhibitor. 

What Pitobrunibis used for 

Pitobrunib for the treatment of adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) who  have received at least two prior lines of therapy, including a Bruton's tyrosine kinase (BTK) inhibitor and a BCL-2 inhibitor.

2.How to take Pitobrunib

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not  sure. Your doctor will tell you what dose of Pitobrunibto take.Your doctor may decide to increase or lower your dose or temporarily  interrupt treatment. Continue treatment at the dose prescribed by your doctor.

*Take Pitobrunib exactly as your healthcare provider tells you.

*Do not change your dose or stop taking Pitobrunib unless your healthcare provider tells you to do so.

*Take Pitobrunib tablets 1 time each day at about the same time each day

*Take Pitobrunib with or without food.

*Swallow Pitobrunib tablets whole with water.Do not cut,crush,or chew the tablets.

If you miss a dose of Pitobrunib,take it as soon as you remember on the same day.If it has been more than 12 hours from the time you usually take Pitobrunib,skip the missed dose,and take your next dose on the next day at your usual time.

3.Side Effects:
Serious Risks:

• Infections: May cause life-threatening infections; monitor for fever, chills, or flu-like symptoms.

• Bleeding: Increased risk of hemorrhage, especially with blood thinners. Seek immediate care for signs like bloody stools, vomiting blood, or severe bruising.

• Cardiac Issues: Atrial fibrillation/flutter may occur, especially in patients with hypertension or prior heart conditions. Report palpitations, chest pain, or shortness of breath.

• Hematologic Effects: Decreased white blood cells, platelets, or red blood cells (common; monitor regularly).

• Secondary Cancers: Risk of new cancers (e.g., skin cancer); use sun protection.

Common Side Effects (≥10%):

• Fatigue, muscle/joint pain, diarrhea, cough, COVID-19 infection, bruising.

Reporting Side Effects: Inform your healthcare provider of any adverse reactions, including those not listed in the leaflet.

Always follow your doctor’s instructions and do not alter the dose without consultation.